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Considering the new recommendations from the CDC about what vaccinated people can do, I'm wondering about how young, healthy (unvaccinated) children would factor into a few scenarios. Do you consider it to be safe for young children (say in the 2-6-year-old range) to play together unmasked indoors if one set of high-risk parents is vaccinated, but the other set of low-risk parents is not? What if vaccinated grandparents are seeing two sets of grandchildren separately unmasked? Is this safe for the children or do you recommend a two-week quarantine between the grandparents seeing the grandchildren from different households in this manner?

The recent CDC recommendations are guidelines for proper behavior for the fully vaccinated—it is expected that as more of the population are vaccinated that these recommendations will change and allow more interaction. The scenario illustrated by the questioner is contingent upon whether the private setting interaction involves unvaccinated persons who have risk of severe COVID-19.

If the unvaccinated people are from a single household that does not have individuals at risk of severe COVID-19, they can visit with fully vaccinated people indoors, without anyone wearing masks, with a low risk of SARS-CoV-2 transmission.  On the other hand, if any of the unvaccinated people or their household members are at increased risk of severe COVID-19, all attendees should take precautions including wearing a well-fitted mask, staying at least 6 feet away from others, and visiting outdoors or in a well-ventilated space.  In between any private setting visit between households, all persons should continue to practice physical distancing, masking, and hand hygiene when out in the general public—in other words, the guidance is only for allowances in private controlled settings of small groups (2 households).

The detailed instructions from the CDC are at this link. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/fully-vaccinated-guidance.html#anchor_1615143349134